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KMID : 0043320090320010043
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Archives of Pharmacal Research
2009 Volume.32 No. 1 p.43 ~ p.47
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Diacylglycerol Acyltransferase-Inhibitory Compounds from Erythrina senegalensis
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Lee Hyun-Sun
Oh Won-Keun
Kang Jong-Seong
Lee Chul-Ho
Fomum Z.Tanee
Cui Long
Jeong Mi-Yeon
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Abstract
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Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2-4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors.
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KEYWORD
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Erythrina senegalensis, Prenylflavonoid, Diacylglycerol acyltransferase
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